All eyes were on Messi after a summer in which he had asked to leave the club and only two days after he had criticized the departure of Luis Suarez, but Fati was the star of the show.
Other games played on Wednesday sees Atletico Madrid (and Luis Suarez fresh from two goals on his debut) travel to face recently promoted Huesca, while Villarreal entertain Alaves, who are without a win so far this season and Eibar are at home to Elche.
Inter coach Antonio Conte started new arrival Aleksandar Kolarov but benched fellow summer signings Arturo Vidal and Achraf Hakimi, while Romelu Lukaku partnered Lautaro Martinez up front with Christian Eriksen behind them.
The single-leg match was played behind closed doors in the central city of Petah Tikva, after Beer Sheva's Turner stadium in southern Israel was closed in June due to structural concerns.
Shijiazhuang will go to the Dalian division, where the relegation competition is held. Their first opponent is Dalian Pro, coached by Spaniard Rafael Benitez.
"We will have a short break before resuming training on October 5, we will try our best to win the game no matter who are our upcoming rivals," said Wu Xinghan of Shandong Luneng. Enditem
"I always thought that one year it has to come. Especially when I won against such great players, I have big respect for both of them. I never played against Vika before. I watch her many times in the TV, even when I was not on the tour. When I was younger, I watched many of her matches," added the 26-year-old.
The other two German participants - RB Leipzig and Borussia Monchengladbach - have harder tasks in Groups F and B respectively.
There was controversy before the race had even started, as it emerged that Hamilton was under investigation for making two practise starts outside the permitted area of the pit lane on his way to the starting grid.
Other media mention former Schalke hero and Belgian, Cote d'Ivorian and Iranian national coach Marc Wilmots as a candidate.
However, that goal only served to pique Liverpool and Sadio Mane drew them level with a simple volleyed finish after Leno did well to parry a shot from Mohamed Salah on the break.